CTech™ Integrated Analytical Solutions

CTech™— Tangential Flow Filtration System with In-Line Protein Concentration Management

Introducing the KrosFlo® KR2i RPM™ System

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Finally, a Tangential Flow Filtration (TFF) system that monitors concentration during your UF/DF run. No longer are you dependent solely on mass inputs and off-line fixed-pathlength UV-Vis spectrophotometers. Now, you can measure what truly matters in real-time: your concentration.

Slope Spectroscopy® Method

Change the Way You Measure Concentration

For decades, ultraviolet visible spectroscopy was the standard for concentration measurement. Traditional uv vis spectrophotometers use a fixed pathlength approach to generate a single absolute absorbance value. But what if you could get more absorbance values, more data points, and ultimately better accuracy? What if you didn’t have to worry about sample dilution, contamination, and other errors? 

The solution is here — the Slope Spectroscopy® method can change the way you measure concentration.

CTech FlowVPX®

In-line GMP testing — Designed to meet the rigors of regulatory GMP requirements, the new CTech FlowVPX spectrophotometer system offers reliable real-time results with integrated ease for concentration measurements during every stage of the downstream GMP process.

Product Details

CTech FlowVPE®

In-line testing — The CTech FlowVPE® System uses the power of Slope Spectroscopy for online process monitoring and PAT fields. Offering process insights and enabling innovation, the FlowVPE helps accelerate development, reduce risk, and increase process efficiency.

Product Details

CTech SoloVPE®

At-line GMP and non-GMP testing — The CTech SoloVPE® System unlocks the power of Slope Spectroscopy with its unique and patented variable pathlength technology (VPT). Avoid costly dilution with this simple, yet empowering variable pathlength solution that delivers rapid and accurate results.

Product Details

Slope Spectroscopy using Variable Pathlength Technology

Change the variable, not the sample

Leveraging the power and flexibility of variable pathlength technology, Slope Spectroscopy is a rapid and robust concentration measurement method. Unlike traditional uv vis spectrophotometers, variable pathlength technology allows for our uv vis systems to take multiple reading in real-time. Giving you more absorbance reading, more data points, for better accuracy and more reliable results.

Traditional photometric analysis relies on a single data point at a fixed pathlength. Constraining the pathlength forces the analyst to adjust the sample to ensure it is within the measurement capabilities of the uv vis spectrophotometer. Dilution steps can introduce error due to the variability of techniques and the skill of the analyst. By varying the pathlength with a precision linear stage, Slope Spectroscopy eliminates the need to manipulate the sample and decreases errors. Variable pathlength technology provides an easy alternative to traditional uv vis spectroscopy.

Our Technology

Service & Support

We succeed when our customers succeed

We’re with you all the way. We strive to integrate our technology with your process as efficiently as possible working closely with your team to ensure that the process is not only streamlined, but that the technology is implemented successfully. The passion for what we do is in the product you receive.

Support Services

Products

CTech™ FlowVPX® System

In-line GMP testing

Designed to meet the rigors of regulatory GMP requirements, the new CTech FlowVPX® spectrophotometer system offers reliable real-time results with integrated ease for concentration measurements during every stage of the downstream GMP process.

CTech™ FlowVPE® System

In-line process monitoring and control

The CTech™ FlowVPE® System uses the power of Slope Spectroscopy for online process monitoring and PAT fields. Offering process insights and enabling innovation, the FlowVPE helps accelerate development, reduce risk, and increase process efficiency.

CTech™ SoloVPE® System

At-line GMP and non-GMP testing

The CTech™ SoloVPE® System unlocks the power of Slope Spectroscopy with its unique and patented variable pathlength technology (VPT). Avoid costly dilution with this simple, yet empowering variable pathlength solution that delivers rapid and accurate results.

KrosFlo® KR2i RPM™ System

TFF with In-Line Protein Concentration Management

Monitor concentration in real time during your UF/DF run. Featuring in-line protein concentration management, control your process with the power of the KrosFlo® KR2i TFF System and insights from the integrated CTech™ FlowVPX® System.

ViPER® ANLYTX Software

The CTechTM ViPER® ANLYTX platform is designed with an app-based architecture where each app is designed for a dedicated purpose. One software platform for all your analytical needs. Our software allows for easy interpretation of sample data, providing key insights that are automatically generated from absorbance over pathlength and display slope, R2, wavelength, concentration, extinction coefficient (if known) and specific users results. Everything you need to take action within your process.

CTech™ VPT Consumables

Elevate your lab with top-of-the-line consumables tailored for the SoloVPE and FlowVPX systems, ensuring pristine measurements and accuracy in your scientific endeavors.

Applications

Gold Particle Testing

SoloVPE systems can be used for Gold particle testing, a highly effective method to validate filters and process integrity in biopharmaceutical manufacturing

SoloVPE Protein A280

The SoloVPE System can accurately measure a wide range of concentrations without any dilution or baseline correction and with reliable and reproducible results.

Polysorbate Analysis

CTech™ SoloVPE System enables the PS80 and PS20 stock solution to be measured without dilution and highly reproducible results through variable pathlength technology.

Quantitation of Nucleic Acids

The CTech SoloVPE System has been proven to be accurate, precise, and robust for the quantitation of nucleic acids, such as DNA, RNA, and Oligonucleotide.

FlowVPE Protein A280

CTech™ FlowVPE® System, a variable pathlength device, allows for inline real-time concentration measurement (A280), as part of a Process Analytical Technology strategy.

Multicomponent Analysis

SoloVPE System’s variable pathlength technology allows multiple hemoglobin components to be measured simultaneously without the need for baseline correction, scatter correction, or dilution

Plasmid DNA Purity

SoloVPE enables quick, precise plasmid purity characterization with no dilution needed. Proprietary variable pathlength technology ensures reliable, consistent results.

Drug-to-antibody Ratio (DAR)

The SoloVPE System provides accurate, precise, and robust concentration measurements of Antibody-Drug Conjugates (ADCs) and Drug-to-Antibody Ratio (DAR).